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Vernal keratoconjunctivitis in school children in Rwanda and its association with socio-economic status: a population-based survey

机译:卢旺达学龄儿童春季角膜结膜炎及其与社会经济地位的关系:一项基于人群的调查

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摘要

Vernal keratoconjunctivitis (VKC) is an allergic eye disease and an important cause of hospital referral among children in Africa and Asia. Hospital-based studies have suggested a role for parasites in its pathogenesis. To determine the prevalence and risk factors for VKC in Central Africa, we conducted a nested population-based case control study in Rwanda, involving randomly selected primary schools from different environments (rural/urban) and climate. A prevalence of VKC of 4.0% (95% confidence interval 3.3-4.7%) was found among 3,041 children studied (participation rate 94.7%). The intestinal parasitic burden was not related to VKC. Besides hot dry climate (odds ratio [OR] = 1.5, P = 0.05) and male gender (OR = 1.7, P = 0.005), multivariate analysis identified higher economic status as a risk for VKC (OR = 1.4, P = 0.005). The effect on VKC of higher economic status appears not to act through differences in parasitic intestinal load.
机译:春季角膜结膜炎(VKC)是一种过敏性眼病,是非洲和亚洲儿童转诊医院的重要原因。基于医院的研究表明,寄生虫在其发病机理中发挥了作用。为了确定中非地区VKC的患病率和风险因素,我们在卢旺达进行了基于人口的嵌套病例对照研究,涉及来自不同环境(农村/城市)和气候的随机选择的小学。在研究的3,041名儿童中,VKC的患病率为4.0%(95%的置信区间为3.3-4.7%)(参与率94.7%)。肠道寄生虫负担与VKC无关。除了炎热干燥的气候(优势比[OR] = 1.5,P = 0.05)和男性(OR = 1.7,P = 0.005)之外,多变量分析还发现较高的经济地位是VKC的风险(OR = 1.4,P = 0.005) 。较高的经济地位对VKC的影响似乎不是通过寄生肠负荷的差异而起作用。

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